https://salilab。org/modeller/About MODELLERMODELLER is used for homology or comparative modeling of proteinthree-dimensional structures (1,2)。 The user provides an alignment of asequence to be modeled
pc蛋蛋注册MODELLER is used for homology or comparative modeling of protein three-dimensional structures (1,2). The user provides an alignment of a sequence to be modeled with known related structures and MODELLER automatically calculates a model containing all non-hydrogen atoms. MODELLER implements comparative protein structure modeling by satisfaction of spatial restraints (3,4), and can perform many additional tasks, including de novo modeling of loops in protein structures, optimization of various models of protein structure with respect to a flexibly defined objective function, multiple alignment of protein sequences and/or structures, clustering, searching of sequence databases, comparison of protein structures, etc. MODELLER is for most Unix/Linux systems, Windows, and Mac.
pc蛋蛋注册Several graphical interfaces to MODELLER are. There are also many other in graphical or web interfaces or other frameworks.
B. Webb, A. Sali. Comparative Protein Structure Modeling Using Modeller. Current Protocols in Bioinformatics, John Wiley & Sons, Inc., 5.6.1-5.6.32, 2014.
M。A。 Marti-Renom, A。 Stuart, A。 Fiser, R。 Sánchez, F。 Melo, A。 Sali。 Comparative protein structure modeling of genes and genomes。 Annu。 Rev。 Biophys。 Biomol。 Struct。 29, 291-325, 2000。
pc蛋蛋注册A. Sali & T.L. Blundell. Comparative protein modelling by satisfaction of spatial restraints. J. Mol. Biol. 234, 779-815, 1993.
A. Fiser, R.K. Do, & A. Sali. Modeling of loops in protein structures, Protein Science 9. 1753-1773, 2000.
The current release of Modeller is 9.18pc蛋蛋注册, which was released on Feb 22nd, 2017. Modeller is currently maintained by.